2. Signaling Pathways
  3. GPCR/G Protein
  4. P2Y Receptor

P2Y Receptor

P2Y Receptor

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P2Y receptors are a class of G protein-coupled receptors (GPCRs) activated by extracellular nucleotides (ATP, UTP, and UDP). There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). The P2Y receptors are expressed in various cell types and play important roles in physiology and pathophysiology including inflammatory responses and neuropathic pain.

The P2Y family can be further divided into a subfamily of five P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs (“P2Y1-like”) that stimulate phospholipase C (PLC) through Gq protein and a second subfamily of P2Y12, P2Y13, and P2Y14Rs (“P2Y12-like”) that inhibit adenylate cyclase through Gi protein. Other effector pathways have been documented, such as coupling of the P2Y11R to Gs as well as to Gq in some cells to induce stimulation of cyclic AMP production.

P2Y Receptor Isoform Specific Products:

P2Y Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-RS09921
    P2ry12 Rat Pre-designed siRNA Set A
    		Inhibitor

    P2ry12 Rat Pre-designed siRNA Set A contains three designed siRNAs for P2ry12 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry12 Rat Pre-designed siRNA Set A
  • HY-170950
    P2Y14 antagonist 1
    		Inhibitor
    P2Y14 antagonist 1 (compound 45) is a high selective and orally active P2Y14R antagonist with an IC50 of 0.70 nM. P2Y14R antagonist 1 demonstrates significant anti-inflammatory efficacy, effectively mitigating the pulmonary infiltration of immune cells and inflammatory response through suppressing the NLRP3 signaling pathway. P2Y14R antagonist 1 has the potential for the research of acute lung injury.
    P2Y14 antagonist 1
  • HY-RS09926
    P2ry14 Mouse Pre-designed siRNA Set A
    		Inhibitor

    P2ry14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for P2ry14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry14 Mouse Pre-designed siRNA Set A
  • HY-RS09922
    P2RY13 Human Pre-designed siRNA Set A
    		Inhibitor

    P2RY13 Human Pre-designed siRNA Set A contains three designed siRNAs for P2RY13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2RY13 Human Pre-designed siRNA Set A
  • HY-161343
    HDL-16
    		Antagonist 99.19%
    HDL-16 is a potent P2Y14R antagonist with an IC50 of 0.3095 nM. HDL-16 ameliorates DSS (HY-116282C)-induced colitis through suppressing necroptosis of intestinal epithelium cells (IECs) and protecting mucosal barrier function.
    HDL-16
  • HY-174977
    P2Y12R ligand-1
    		Ligand
    P2Y12R ligand-1 (Compound 41) is a high-affinity P2Y12R ligand with a Ki value of 17.1 nM. P2Y12R ligand-1 labeled with [18F] can be used in studies of brain PET imaging.
    P2Y12R ligand-1
  • HY-15284S2
    Prasugrel-d4
    Prasugrel-d4 is the deuterium labeled Prasugrel. Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.
    Prasugrel-d<sub>4</sub>
  • HY-176143
    P2Y1/P2Y6 antagonist 1
    		Antagonist
    P2Y1/P2Y6 antagonist 1 (Compound 3h) is an indolesulfonylhydrazide derivative. P2Y1/P2Y6 antagonist 1 is an orally active tP2Y1 and rP2Y6 antagonist (IC50 of 9.72 and 1.89 μM, respectively). P2Y1/P2Y6 antagonist 1 can be used in the study of neurological diseases, inflammation, cardiovascular diseases and cancer.
    P2Y1/P2Y6 antagonist 1
  • HY-108654
    PSB 0474
    		Agonist
    PSB 0474 (3-phenacyl-UDP) is a selective and potent P2Y6 receptor agonist with an EC50 of 70 nM. PSB 0474 inhibits cell proliferation, increases NO release in astrocytes and microglia cells. PSB 0474 induces astrocytes apoptosis.
    PSB 0474
  • HY-RS09916
    P2ry1 Rat Pre-designed siRNA Set A
    		Inhibitor

    P2ry1 Rat Pre-designed siRNA Set A contains three designed siRNAs for P2ry1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry1 Rat Pre-designed siRNA Set A
  • HY-117356A
    MRS2693 ammonium
    		Agonist
    MRS2693 ammonium is the ammonium dalt form of MRS2693 (HY-117356). MRS2693 ammonium is a selective agonist for P2Y6 with an EC50 of 0.015 μM. MRS2693 ammonium protects C2C12 skeletal muscle cells from TNFα-induced apoptosis. MRS2693 ammonium reduces the activation of NF-kB, activates the ERK1/2 pathway, and has a cytoprotective effect on mouse ischemia-reperfusion injury model[2].
    MRS2693 ammonium
  • HY-15284S
    Prasugrel-d5
    		Inhibitor
    Prasugrel-d5 is deuterium labeled Prasugrel. Prasugrel (PCR 4099), a thienopyridine and prodrug, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.
    Prasugrel-d<sub>5</sub>
  • HY-RS09925
    P2RY14 Human Pre-designed siRNA Set A
    		Inhibitor

    P2RY14 Human Pre-designed siRNA Set A contains three designed siRNAs for P2RY14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2RY14 Human Pre-designed siRNA Set A
  • HY-B0606A
    Diquafosol
    		Agonist
    Diquafosol (INS365 free base) is a potent P2Y2 agonist. Diquafosol nhibits apoptosis and decreases ROS generation. Diquafosol has the potential for the research of dry eye.
    Diquafosol
  • HY-RS09933
    P2ry4 Rat Pre-designed siRNA Set A
    		Inhibitor

    P2ry4 Rat Pre-designed siRNA Set A contains three designed siRNAs for P2ry4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry4 Rat Pre-designed siRNA Set A
  • HY-168139
    MRS4865
    		Antagonist
    MRS4865 (compund 7a) is a chimera of a P2Y14 receptor antagonist and a UDP-glucose agonist that protects against neuropathic pain.
    MRS4865
  • HY-172226
    P2Y14R antagonist 3
    		Antagonist
    P2Y14R antagonist 3 (Compound A) is a potent and orally active P2Y14R antagonist with an IC50 value of 23.60 nM and a Kd value of 7.26 μM. P2Y14R antagonist 3 can reduce the degree of lung injury in the Lipopolysaccharides (LPS) (HY-D1056)-induced acute lung injury mice. P2Y14R antagonist 3 can be used for inflammatory diseases.
    P2Y14R antagonist 3
  • HY-103055
    PPTN mesylate
    		Antagonist
    PPTN mesylate is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN mesylate exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity.
    PPTN mesylate
  • HY-172417
    Becondogrel
    		Antagonist
    Becondogrel (2-Oxoclopidogrel) is the metabolite of Clopidogrel (HY-15283). Becondogrel irreversibly inhibits P2Y12 receptor, thereby inhibiting platelet aggregation and thrombosis.
    Becondogrel
  • HY-107867S1
    (Rac)-Clopidogrel hydrogen-d9 sulfate
    (Rac)-Clopidogrel hydrogen-d9 sulfate is the deuterium labeled (±)-Clopidogrel (bisulfate) (HY-107867). (±)-Clopidogrel bisulfate is a platelet P2Y12 receptor inhibitor and an adenosine diphosphate (ADP) receptor antagonist. (±)-Clopidogrel bisulfate inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel bisulfate reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. (±)-Clopidogrel bisulfate has anti-inflammatory effects.
    (Rac)-Clopidogrel hydrogen-d<sub>9</sub> sulfate
Cat. No. Product Name / Synonyms Application Reactivity
P2Y Receptor Isoform Comparison

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