2. Signaling Pathways
  3. GPCR/G Protein
  4. P2Y Receptor

P2Y Receptor

P2Y Receptor

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P2Y receptors are a class of G protein-coupled receptors (GPCRs) activated by extracellular nucleotides (ATP, UTP, and UDP). There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). The P2Y receptors are expressed in various cell types and play important roles in physiology and pathophysiology including inflammatory responses and neuropathic pain.

The P2Y family can be further divided into a subfamily of five P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs (“P2Y1-like”) that stimulate phospholipase C (PLC) through Gq protein and a second subfamily of P2Y12, P2Y13, and P2Y14Rs (“P2Y12-like”) that inhibit adenylate cyclase through Gi protein. Other effector pathways have been documented, such as coupling of the P2Y11R to Gs as well as to Gq in some cells to induce stimulation of cyclic AMP production.

P2Y Receptor Isoform Specific Products:

P2Y Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-175675
    P2Y1 antagonist 4
    		Antagonist
    P2Y1 antagonist 4 is a selective P2Y1 receptor antagonist with excellent blood-brain barrier (BBB) penetration. P2Y1 antagonist 4 inhibits P2Y1 receptor-mediated cytosolic Ca2+ increase (IC50 = 1.95 μM) and platelet aggregation (IC50 = 3.24 μM) induced by ADP in rabbit washed platelets. P2Y1 antagonist 4 significantly upregulates the level of nuclear Nrf2 protein in H2O2-treated HT22 cells. P2Y1 antagonist 4 reduces myocardial infarct size in a mouse acute myocardial infarction (MI) model. P2Y1 antagonist 4 can be used for the study of ischemic stroke and myocardial infarction.
    P2Y1 antagonist 4
  • HY-108648A
    2-MeSADP
    		Agonist
    2-MeSADP (2-Methylthioadenosine diphosphate; 2-Methylthio-ADP) is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-MeSADP has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-MeSADP induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1.
    2-MeSADP
  • HY-RS09923
    P2ry13 Mouse Pre-designed siRNA Set A
    		Inhibitor

    P2ry13 Mouse Pre-designed siRNA Set A contains three designed siRNAs for P2ry13 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry13 Mouse Pre-designed siRNA Set A
  • HY-RS09920
    P2ry12 Mouse Pre-designed siRNA Set A
    		Inhibitor

    P2ry12 Mouse Pre-designed siRNA Set A contains three designed siRNAs for P2ry12 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry12 Mouse Pre-designed siRNA Set A
  • HY-108650
    2-Thio-UTP tetrasodium
    		Agonist
    2-Thio-UTP tetrasodium is a potent P2Y2, P2Y4 and P2Y6 agonist, which an be used for the research of cancer.
    2-Thio-UTP tetrasodium
  • HY-RS09914
    P2RY1 Human Pre-designed siRNA Set A
    		Inhibitor

    P2RY1 Human Pre-designed siRNA Set A contains three designed siRNAs for P2RY1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2RY1 Human Pre-designed siRNA Set A
  • HY-RS09927
    P2ry14 Rat Pre-designed siRNA Set A
    		Inhibitor

    P2ry14 Rat Pre-designed siRNA Set A contains three designed siRNAs for P2ry14 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry14 Rat Pre-designed siRNA Set A
  • HY-RS09921
    P2ry12 Rat Pre-designed siRNA Set A
    		Inhibitor

    P2ry12 Rat Pre-designed siRNA Set A contains three designed siRNAs for P2ry12 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry12 Rat Pre-designed siRNA Set A
  • HY-170950
    P2Y14 antagonist 1
    		Inhibitor
    P2Y14 antagonist 1 (compound 45) is a high selective and orally active P2Y14R antagonist with an IC50 of 0.70 nM. P2Y14R antagonist 1 demonstrates significant anti-inflammatory efficacy, effectively mitigating the pulmonary infiltration of immune cells and inflammatory response through suppressing the NLRP3 signaling pathway. P2Y14R antagonist 1 has the potential for the research of acute lung injury.
    P2Y14 antagonist 1
  • HY-RS09926
    P2ry14 Mouse Pre-designed siRNA Set A
    		Inhibitor

    P2ry14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for P2ry14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry14 Mouse Pre-designed siRNA Set A
  • HY-RS09922
    P2RY13 Human Pre-designed siRNA Set A
    		Inhibitor

    P2RY13 Human Pre-designed siRNA Set A contains three designed siRNAs for P2RY13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2RY13 Human Pre-designed siRNA Set A
  • HY-137612C
    Rp-UTP-α-S tetrasodium
    		Agonist
    Rp-UTP-α-S (tetrasodium) is a nucleotide agonist of purinergic P2Y2 and P2Y4 receptors. Rp-UTP-α-S (tetrasodium) can induce inositol phosphate accumulation in P2Y2 or P2Y4 expressing 1321N1 cells with EC50 values of 5.4 and 27 μM.
    Rp-UTP-α-S tetrasodium
  • HY-161343
    HDL-16
    		Antagonist 99.19%
    HDL-16 is a potent P2Y14R antagonist with an IC50 of 0.3095 nM. HDL-16 ameliorates DSS (HY-116282C)-induced colitis through suppressing necroptosis of intestinal epithelium cells (IECs) and protecting mucosal barrier function.
    HDL-16
  • HY-174977
    P2Y12R ligand-1
    		Ligand
    P2Y12R ligand-1 (Compound 41) is a high-affinity P2Y12R ligand with a Ki value of 17.1 nM. P2Y12R ligand-1 labeled with [18F] can be used in studies of brain PET imaging.
    P2Y12R ligand-1
  • HY-15284S2
    Prasugrel-d4
    Prasugrel-d4 is the deuterium labeled Prasugrel. Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.
    Prasugrel-d<sub>4</sub>
  • HY-176143
    P2Y1/P2Y6 antagonist 1
    		Antagonist
    P2Y1/P2Y6 antagonist 1 (Compound 3h) is an indolesulfonylhydrazide derivative. P2Y1/P2Y6 antagonist 1 is an orally active tP2Y1 and rP2Y6 antagonist (IC50 of 9.72 and 1.89 μM, respectively). P2Y1/P2Y6 antagonist 1 can be used in the study of neurological diseases, inflammation, cardiovascular diseases and cancer.
    P2Y1/P2Y6 antagonist 1
  • HY-108654
    PSB 0474
    		Agonist
    PSB 0474 (3-phenacyl-UDP) is a selective and potent P2Y6 receptor agonist with an EC50 of 70 nM. PSB 0474 inhibits cell proliferation, increases NO release in astrocytes and microglia cells. PSB 0474 induces astrocytes apoptosis.
    PSB 0474
  • HY-RS09916
    P2ry1 Rat Pre-designed siRNA Set A
    		Inhibitor

    P2ry1 Rat Pre-designed siRNA Set A contains three designed siRNAs for P2ry1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry1 Rat Pre-designed siRNA Set A
  • HY-117356A
    MRS2693 ammonium
    		Agonist
    MRS2693 ammonium is the ammonium dalt form of MRS2693 (HY-117356). MRS2693 ammonium is a selective agonist for P2Y6 with an EC50 of 0.015 μM. MRS2693 ammonium protects C2C12 skeletal muscle cells from TNFα-induced apoptosis. MRS2693 ammonium reduces the activation of NF-kB, activates the ERK1/2 pathway, and has a cytoprotective effect on mouse ischemia-reperfusion injury model[2].
    MRS2693 ammonium
  • HY-15284S
    Prasugrel-d5
    		Inhibitor
    Prasugrel-d5 is deuterium labeled Prasugrel. Prasugrel (PCR 4099), a thienopyridine and prodrug, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.
    Prasugrel-d<sub>5</sub>
Cat. No. Product Name / Synonyms Application Reactivity
P2Y Receptor Isoform Comparison

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