2. Signaling Pathways
  3. GPCR/G Protein
  4. P2Y Receptor

P2Y Receptor

P2Y Receptor

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P2Y receptors are a class of G protein-coupled receptors (GPCRs) activated by extracellular nucleotides (ATP, UTP, and UDP). There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). The P2Y receptors are expressed in various cell types and play important roles in physiology and pathophysiology including inflammatory responses and neuropathic pain.

The P2Y family can be further divided into a subfamily of five P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs (“P2Y1-like”) that stimulate phospholipase C (PLC) through Gq protein and a second subfamily of P2Y12, P2Y13, and P2Y14Rs (“P2Y12-like”) that inhibit adenylate cyclase through Gi protein. Other effector pathways have been documented, such as coupling of the P2Y11R to Gs as well as to Gq in some cells to induce stimulation of cyclic AMP production.

P2Y Receptor Isoform Specific Products:

P2Y Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-161343
    HDL-16
    		Antagonist 99.19%
    HDL-16 is a potent P2Y14R antagonist with an IC50 of 0.3095 nM. HDL-16 ameliorates DSS (HY-116282C)-induced colitis through suppressing necroptosis of intestinal epithelium cells (IECs) and protecting mucosal barrier function.
    HDL-16
  • HY-15284S2
    Prasugrel-d4
    Prasugrel-d4 is the deuterium labeled Prasugrel. Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.
    Prasugrel-d<sub>4</sub>
  • HY-176143
    P2Y1/P2Y6 antagonist 1
    		Antagonist
    P2Y1/P2Y6 antagonist 1 (Compound 3h) is an indolesulfonylhydrazide derivative. P2Y1/P2Y6 antagonist 1 is an orally active tP2Y1 and rP2Y6 antagonist (IC50 of 9.72 and 1.89 μM, respectively). P2Y1/P2Y6 antagonist 1 can be used in the study of neurological diseases, inflammation, cardiovascular diseases and cancer.
    P2Y1/P2Y6 antagonist 1
  • HY-108654
    PSB 0474
    		Agonist
    PSB 0474 (3-phenacyl-UDP) is a selective and potent P2Y6 receptor agonist with an EC50 of 70 nM. PSB 0474 inhibits cell proliferation, increases NO release in astrocytes and microglia cells. PSB 0474 induces astrocytes apoptosis.
    PSB 0474
  • HY-RS09916
    P2ry1 Rat Pre-designed siRNA Set A
    		Inhibitor

    P2ry1 Rat Pre-designed siRNA Set A contains three designed siRNAs for P2ry1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry1 Rat Pre-designed siRNA Set A
    P2ry1 Rat Pre-designed siRNA Set A
  • HY-117356A
    MRS2693 ammonium
    		Agonist
    MRS2693 ammonium is the ammonium dalt form of MRS2693 (HY-117356). MRS2693 ammonium is a selective agonist for P2Y6 with an EC50 of 0.015 μM. MRS2693 ammonium protects C2C12 skeletal muscle cells from TNFα-induced apoptosis. MRS2693 ammonium reduces the activation of NF-kB, activates the ERK1/2 pathway, and has a cytoprotective effect on mouse ischemia-reperfusion injury model[2].
    MRS2693 ammonium
  • HY-15284S
    Prasugrel-d5
    		Inhibitor
    Prasugrel-d5 is deuterium labeled Prasugrel. Prasugrel (PCR 4099), a thienopyridine and prodrug, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation.
    Prasugrel-d<sub>5</sub>
  • HY-RS09925
    P2RY14 Human Pre-designed siRNA Set A
    		Inhibitor

    P2RY14 Human Pre-designed siRNA Set A contains three designed siRNAs for P2RY14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2RY14 Human Pre-designed siRNA Set A
    P2RY14 Human Pre-designed siRNA Set A
  • HY-B0606A
    Diquafosol
    		Agonist
    Diquafosol (INS365 free base) is a potent P2Y2 agonist. Diquafosol nhibits apoptosis and decreases ROS generation. Diquafosol has the potential for the research of dry eye.
    Diquafosol
  • HY-RS09933
    P2ry4 Rat Pre-designed siRNA Set A
    		Inhibitor

    P2ry4 Rat Pre-designed siRNA Set A contains three designed siRNAs for P2ry4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry4 Rat Pre-designed siRNA Set A
    P2ry4 Rat Pre-designed siRNA Set A
  • HY-168139
    MRS4865
    		Antagonist
    MRS4865 (compund 7a) is a chimera of a P2Y14 receptor antagonist and a UDP-glucose agonist that protects against neuropathic pain.
    MRS4865
  • HY-172226
    P2Y14R antagonist 3
    		Antagonist
    P2Y14R antagonist 3 (Compound A) is a potent and orally active P2Y14R antagonist with an IC50 value of 23.60 nM and a Kd value of 7.26 μM. P2Y14R antagonist 3 can reduce the degree of lung injury in the Lipopolysaccharides (LPS) (HY-D1056)-induced acute lung injury mice. P2Y14R antagonist 3 can be used for inflammatory diseases.
    P2Y14R antagonist 3
  • HY-103055
    PPTN mesylate
    		Antagonist
    PPTN mesylate is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN mesylate exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity.
    PPTN mesylate
  • HY-172417
    Becondogrel
    		Antagonist
    Becondogrel (2-Oxoclopidogrel) is the metabolite of Clopidogrel (HY-15283). Becondogrel irreversibly inhibits P2Y12 receptor, thereby inhibiting platelet aggregation and thrombosis.
    Becondogrel
  • HY-15876R
    Clopidogrel thiolactone (Standard)
    		Inhibitor
    Cyhalofop (Standard) is the analytical standard of Cyhalofop. This product is intended for research and analytical applications. Cyhalofop (Cyhalofop acid), the primary metabolite of Cyhalofop-butyl (HY-B0861) in susceptible grasses, is the herbicidally active metabolite. Cyhalofop-butyl is an aryloxyphenoxypropionate post-emergence herbicide widely used around the world in agriculture.
    Clopidogrel thiolactone (Standard)
  • HY-110092A
    PSB-1114 triethylamine
    		Agonist
    PSB-1114 triethylamine is a potent, enzymatically stable, and subtype-selective P2Y2 receptor agonist with an EC50 of 134 nM. PSB-1114 triethylamine displays >50-fold selectivity versus the P2Y4 (EC50 of 9.3 μM) and P2Y6 (EC50 of 7.0 μM) receptors.
    PSB-1114 triethylamine
  • HY-173407
    P2Y14R antagonist 4
    		Antagonist
    P2Y14R antagonist 4 (Compound 25l) is an orally active P2Y14R antagonist (IC50: 5.6 nM) with superior binding affinity to P2Y14R over PPTN. P2Y14R antagonist 4 has anti-inflammatory activity and reduces LPS (HY-D1056)-induced proinflammatory cytokines (IL-1β, IL-6, and TNF-α) release.
    P2Y14R antagonist 4
  • HY-117572
    MRS2567
    		Antagonist
    MRS2567 is a P2Y receptor antagonist with the activity of inhibiting contraction of mouse mesenteric arteries. MRS2567 can inhibit the sustained contraction caused by UTP and UDP, and inhibit the Na+, K+, 2Cl- co-transport-dependent signaling pathway, thereby affecting the myogenic tone of mouse mesenteric arteries.
    MRS2567
  • HY-108657
    MRS2279
    		Antagonist
    MRS2279 is a selective and high affinity P2Y1 receptor antagonist, with a Ki of 2.5 nM and an IC50 of 51.6 nM. MRS2279 competitively inhibits ADP-promoted platelet aggregation with an apparent affnity (pKB=8.05).
    MRS2279
  • HY-108665
    AR-C66096 tetrasodium
    		Antagonist
    AR-C66096 tetrasodium is a selective platelet P2YT receptor antagonist. AR-C66096 tetrasodium effectively blocks ADP-induced platelet aggregation. AR-C66096 tetrasodium can be used in the research of thromboembolism.
    AR-C66096 tetrasodium
Cat. No. Product Name / Synonyms Application Reactivity
P2Y Receptor Isoform Comparison

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